Oral Drug Slows Stargardt Disease Progression in Phase 2 Clinical Trial
Tuesday, March 5 2024 | 08 h 05 min | Vision Science & Research
Results from a Phase 2 clinical trial show that an oral drug, Tinlarebant, may slow progression of Stargardt disease.
Belite Bio, a biopharmaceutical company who sponsored this trial, presented data from 12 patients, aged 12-18, who had been treated with Tinlarebant for 2 years. The study found that Tinlarebant was safe and patients who were taking the drug had reduced retinal atrophy. The majority of patients also had stabilized visual acuity during the trial.
Tinlarebant is a drug that is designed to reduce the accumulation of vitamin A-based toxins (bisretinoides) that can cause retinal degeneration in Stargardt disease and advanced dry age-related macular degeneration (also called geographic atrophy). Tinlarebant is also being studied in a Phase 3 trial (PHOENIX) for geographic atrophy.
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