Gene switch

German researchers have discovered that genes controlling blood vessel growth in the retina of mice are “switched on” by the protein serum response factor (SRF).

 

This is a major finding, as many severe eye diseases are caused by the retina containing either too few or too many blood vessels. The results of the study therefore provide a starting point for the development of treatments for defective retinae and vitreous bodies.

 

The researchers at the University of Tübingen discovered that by eliminating this protein, they could artificially induce a certain disease profile in newborn and adult mice. Among the most interesting aspects of this research are the fact that this procedure produced different results depending on the age of the mouse and the resemblance to human diseases.

 

When the SRF was switched off in embryos or newborns, the blood vessels in the retinae were not fully developed. Their eye problems resembled vitreoretinopathy or Norrie disease. In adult mice, however, the procedure produced too many blood vessels in the retina, leading to a condition similar to that found in people with AMD.

Source: http://www.sciencedaily.com/releases/2013/04/130408133509.htm

Featured Posts

Flirty Cat-Eye Sunnies from OTPS are Totally Trending

OTPS-2031’s Rose Tortoise is a fun and flirty frame created using colourful patterned biodegradable acetate.

Learn More

MIDO 2023: Trends, Awards and Celebrities Energize Eyewear Show

Great turnout on the first day of MIDO. Business, trends, fashion, and much more – awards, celebrities and many events, Friday, February 3, through Monday 6 th at Fiera Milano Rho.

Read more

25,700+ Accept WCO Myopia Management Standard of Care Pledge Challenge

Global Organizations and Eye Care Professionals Pledge to Embrace the Three Pillars of Myopia Management

Read more

February is AMD Awareness Month Recognizing the Leading Cause of Vision Loss in Seniors

Fighting Blindness Canada (FBC) is marking Age-Related Macular Degeneration (AMD) Awareness Month with activities to inform and educate Canadians about the leading cause of vision loss in people over the age of 55, impacting approximately 2.5 million Canadians.

Read more

MIDO 2023 is Ready: All Eyes on the International Eyewear Show

Appointment with MIDO at Fiera Milano Rho Saturday, February 4 to Monday, February 6

Read more

Flirty Cat-Eye Sunnies from OTPS are Totally Trending

OTPS-2031’s Rose Tortoise is a fun and flirty frame created using colourful patterned biodegradable acetate.

Learn More

MIDO 2023: Trends, Awards and Celebrities Energize Eyewear Show

Great turnout on the first day of MIDO. Business, trends, fashion, and much more – awards, celebrities and many events, Friday, February 3, through Monday 6 th at Fiera Milano Rho.

Read More

25,700+ Accept WCO Myopia Management Standard of Care Pledge Challenge

Global Organizations and Eye Care Professionals Pledge to Embrace the Three Pillars of Myopia Management

Read More

February is AMD Awareness Month Recognizing the Leading Cause of Vision Loss in Seniors

Fighting Blindness Canada (FBC) is marking Age-Related Macular Degeneration (AMD) Awareness Month with activities to inform and educate Canadians about the leading cause of vision loss in people over the age of 55, impacting approximately 2.5 million Canadians.

Read More

MIDO 2023 is Ready: All Eyes on the International Eyewear Show

Appointment with MIDO at Fiera Milano Rho Saturday, February 4 to Monday, February 6

Read More

Flirty Cat-Eye Sunnies from OTPS are Totally Trending

OTPS-2031’s Rose Tortoise is a fun and flirty frame created using colourful patterned biodegradable acetate.

Learn More

MIDO 2023: Trends, Awards and Celebrities Energize Eyewear Show

Great turnout on the first day of MIDO. Business, trends, fashion, and much more – awards, celebrities and many events, Friday, February 3, through Monday 6 th at Fiera Milano Rho.

Read more

25,700+ Accept WCO Myopia Management Standard of Care Pledge Challenge

Global Organizations and Eye Care Professionals Pledge to Embrace the Three Pillars of Myopia Management

Read more

February is AMD Awareness Month Recognizing the Leading Cause of Vision Loss in Seniors

Fighting Blindness Canada (FBC) is marking Age-Related Macular Degeneration (AMD) Awareness Month with activities to inform and educate Canadians about the leading cause of vision loss in people over the age of 55, impacting approximately 2.5 million Canadians.

Read more

MIDO 2023 is Ready: All Eyes on the International Eyewear Show

Appointment with MIDO at Fiera Milano Rho Saturday, February 4 to Monday, February 6

Read more

Flirty Cat-Eye Sunnies from OTPS are Totally Trending

OTPS-2031’s Rose Tortoise is a fun and flirty frame created using colourful patterned biodegradable acetate.

Learn More

MIDO 2023: Trends, Awards and Celebrities Energize Eyewear Show

Great turnout on the first day of MIDO. Business, trends, fashion, and much more – awards, celebrities and many events, Friday, February 3, through Monday 6 th at Fiera Milano Rho.

Read more

25,700+ Accept WCO Myopia Management Standard of Care Pledge Challenge

Global Organizations and Eye Care Professionals Pledge to Embrace the Three Pillars of Myopia Management

Read more

February is AMD Awareness Month Recognizing the Leading Cause of Vision Loss in Seniors

Fighting Blindness Canada (FBC) is marking Age-Related Macular Degeneration (AMD) Awareness Month with activities to inform and educate Canadians about the leading cause of vision loss in people over the age of 55, impacting approximately 2.5 million Canadians.

Read more

MIDO 2023 is Ready: All Eyes on the International Eyewear Show

Appointment with MIDO at Fiera Milano Rho Saturday, February 4 to Monday, February 6

Read more