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OcuBlink Wins Seed Funding from Two Prominent Business Accelerators

OcuBlink, Inc., which is developing sophisticated in vitro eye models for ophthalmic testing, has received funding from two prominent business accelerators. The company will use the funds and associated entrepreneurial coaching to scale its business, focused on assisting research centers, pharmaceutical and medical device companies validate ocular products more rapidly and cost-effectively.

AC JumpStart, funded by FedDev Ontario, awarded OcuBlink CAD$30,000 in seed capital and CAD$10,000 of in-kind mentorship. The accelerator helps technology start-ups establish and grow their business in Southern Ontario. OcuBlink was also named one of four winners in the annual Velocity Fund $5K competition, an entrepreneurship program at the University of Waterloo and the most productive start-up incubator in Canada.

OcuBlink began as an initiative of the Centre for Ocular Research & Education (CORE) and now operates as an affiliate, utilizing CORE’s staffing, counsel and laboratories.

“We’ve been developing our novel in vitro platforms since 2014, working with industry partners and researchers to validate our technology. Now it’s time to bring our innovations to market, with the invaluable assistance of AC Jumpstart and the Velocity Fund,” said OcuBlink Chief Executive Officer Hendrik Walther, PhD, MSc, BSc Optom.

Traditional testing uses a vial or a test tube for early stage research, with later pre-clinical studies performed using an animal model. However, vials and test tubes do not remotely resemble the complex structure of the eye, leading to variable outcomes, and increasing regulation and public opinion is limiting animal experimentation. Incorporating OcuBlink to test concepts and prototypes at an earlier stage will minimize costs, reduce animal experimentation, and create deeper understanding of the underlying science of how new and existing products interact with the eye.

For more information, visit OcuBlink.com.

Thinning Retina May Be Early Sign of Parkinson’s

A new study published in Neurology shows that thinning of the nerve cells in the back of the eye is linked to the loss of dopamine producers in the brain.

“Our study is the first to show a link between the thinning of the retina and a known sign of the progression of the disease — the loss of brain cells that produce dopamine,” said study author Jee-Young Lee, MD, PhD, of the Seoul Metropolitan Government – Seoul National University Boramae Medical Center in South Korea. “We also found the thinner the retina, the greater the severity of disease. These discoveries may mean that neurologists may eventually be able to use a simple eye scan to detect Parkinson’s disease in its earliest stages, before problems with movement begin.”

After evaluating 49 individuals (average age 69) who had been diagnosed with Parkinson’s, compared with 54 similarly aged healthy individuals, researchers found notable thinning on the two innermost of the retina’s five layers.

Individuals with more severe Parkinson’s were also found to have more retinal thinning.

“Larger studies are needed to confirm our findings and to determine just why retina thinning and the loss of dopamine-producing cells are linked,” said Lee. “If confirmed, retina scans may not only allow earlier treatment of Parkinson’s disease but more precise monitoring of treatments that could slow progression of the disease as well.”

Read more here.

Wearable Beacon Technology Powers Vision Expo’s New Vision View Program

Vision Expo continues to invest in tools and technologies that allow attendees to personalize their experience and maximize time onsite, while helping exhibitors to increase their return on investment and receive more relevant booth traffic. The Vision View program, set to launch at Vision Expo West (Education: September 26 – 29; Exhibit Hall: September 27 – 29) in Las Vegas, NV, features new wearable beacon technology that will add a variety of benefits for both attendees and exhibitors.

Vision View Benefits for Attendees:

  • Personalized Experience: Booth recommendations will be delivered based on the attendee’s onsite activity and on the activity of similar attendees throughout all three days of the Show. Used in conjunction with pre-show recommendations shared based on interest, attendees can easily identify exhibitors that provide a solution to their needs.
  • Meaningful Networking: Attendees will regularly receive recommendations on who to meet based on similar activities and interests and can automatically and securely exchange contact information and chat directly through the Vision Expo mobile app.
  • Map the Vision Expo Journey: Attendees will receive a personalized journey report showing the people they have interacted with and the booths they visited.

Vision View Benefits for Exhibitors:

  • Increased ROI: Exhibitor booths will be recommended based on attendees’ previous activity and on the type of attendee who has already visited it, helping each booth’s traffic to be more qualified. Vision View, in combination with utilizing the Vision Expo Exhibitor Dashboard, will drive new and relevant traffic to exhibitor booths.
  • Product Gallery Enhancements: Exhibitors who participate in the Product Gallery will be able to have product content digitally delivered to interested attendees in the attendee’s journey report. Exhibitors will also be alerted when key targets are near their booth based on the exhibitor’s selected target criteria.
  • Post-Show Value: Visiting attendees will have exhibitor information in their personalized journey report, allowing for easier recall and follow-up.

Each Vision Expo registration badge will have a unique smart tag that securely broadcasts its location to Vision View hubs and sensors placed throughout the Show. This will provide insights on the types of attendees visiting various booths allowing booth recommendations to be made based on attendee behavior.

Vision View is the newest addition to a variety of digital tools that Vision Expo offers to enhance the Show experience, including the pre-show recommendations program, MyShow Planning Tool and the Vision Expo Mobile App. Each of these tools can be used together to maximize time spent at Vision Expo and improve the quality of recommendations between attendees and exhibitors.

Throughout the Show, attendees can click on Vision View in the Vision Expo mobile app to regularly access booth and networking recommendations and view their journey report.

To learn more about the benefits of Vision View, as well as privacy and opt-out information, click here.

Essilor in India: Meeting Manufacturing Needs Through Solar Energy

The “Soura Shakthi” project (Solar Energy in Hindi) began in October 2017 when Essilor set out to reduce its dependency on conventional fossil fuels by increasing its use of renewable energy. A cross-functional team from EMIL worked with government regulators to achieve the different stages required – from an in-depth risk assessment, due diligence to construction and production. The Rays Power Infra Solar Park in Karnataka was inaugurated on July 4th with a “lighting the lamp” ceremony.

EMIL has a strong track record in sustainability achievements, having reduced its energy consumption by 28% per lens produced over the past six years, as well as decrease the amount of water used by over 30%. The “Saura Shakti” initiative will provide 70% of the plant’s total energy requirements through solar power and reduce CO2 emissions by 4,800 metric tonnes per year.

Reducing greenhouse gas emissions through the use of clean energy sources is one of the ways in which manufacturing sites contribute to the Group’s commitments to climate actions and maintaining its position as a low-carbon company.

Click HERE for the full press release.

Key Tear Film Lipid Identified

In a finding that could signal improved treatments for dry eye, Australian identified, and then synthesized in the lab, an important component of the tear film lipid layer.

While long-chain lipids make only a small portion (around 5%) of the total tear film lipid layer, they are essential for maintaining the ocular clarity of the tear film. Without the presence of these lipids, says said Stephen Blanksby, a professor at the Queensland University of Technology who led the research team in this study, “This clearly wouldn’t be satisfactory for you to look through.”

The exact structure of the lipids, known as (O-acyl)-ω-hydroxy fatty acids, was determined through mass spectrometry, because of the difficulties in obtaining large enough samples from the meibum to run other types of analysis such as nuclear magnetic resonance (NMR) spectroscopy.

Chemist Michael J. Kelso’s group at the University of Wollongong in Australia was able to synthesize the lipid once the exact structure was determined.

The research team is currently working with Allergan, who co-funded the research, to incorporate the newly synthesized lipid into dry eye drops. “This type of work provides a framework to produce a product that mimics, and is based on, the actual components that are present in human tears,” said Blanksby. By creating dry eye drops that more closely mimic a real tear film, Blanksby hopes to alleviate the negative side effects of drops.

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