For the first time, a drug has a real positive impact on patients with metastatic uveal melanoma, a disease often qualified as “untreatable.”

 

The good news came from Memorial Sloan-Kettering Cancer Center, whose research results were presented at the 49th annual meeting of the American Society of Clinical Oncology. Researchers found that progression-free survival in patients treated with selumetinib was nearly 16 weeks, and half of these patients experienced tumour shrinkage, with 15% achieving major shrinkage.

 

In comparison, patients treated with temozolomide, the standard chemotherapy, had seven weeks of progression-free survival and no tumour shrinkage. Selumetinib also lengthened overall survival to 10.8 months versus 9.4 months with temozolomide.

 

“This is the first study to show that a systemic therapy provides significant clinical benefit in a randomized fashion to advanced uveal melanoma patients,” said lead author Richard D. Carvajal.

Source: http://www.mskcc.org/pressroom/press/new-therapy-shown-improve-progression-free-survival-and-shrink-tumors-rare-first-time

Protection against UV rays is important all year long. However, the arrival of sunny summer days is an ideal time for eyecare professionals to remind the public of the risks of overexposure.

 

In the United States, the American Academy of Ophthalmology (AAO) recently issued a warning, urging people to wear sunglasses and a hat when heading outside. They cite a number of studies showing that exposure to the sun’s rays can lead to cataracts, macular degeneration, and even tumours.

 

They also insist on the lesser known danger, photokeratitis, or ultraviolet keratitis, which is like a sunburn of the cornea. It generally takes one to three days to recover from photokeratitis, which is extremely painful. “In far too many cases, people think that a little redness on the skin is not a big deal; but, consider what that burn could feel like on your extremely thin and delicate corneas,” said Philip Rizzuto, secretary for communications for the AAO.  

Source: http://www.aao.org/newsroom/release/20130603.cfm

 

 

The size of retinal blood vessels may indicate brain health, which could help detect early signs of dementia and other cognitive diseases.

 

Scientist Idan Shalev of Duke University wondered whether intelligence might serve as a marker indicating the health of the brain, and specifically the health of the system of blood vessels that provides oxygen and nutrients to the brain. To investigate this idea, he used digital retinal imaging. Retinal blood vessels are similar in size to those in the brain and provide clues to brain health.

 

After testing 1,000 people, the researchers discovered that having wider retinal venules was linked with lower IQ scores at age 38. These individuals had cognitive deficits, including verbal comprehension, perceptual reasoning, working memory and executive functioning.

 

“Digital retinal imaging is a tool that is being used today mainly by eye doctors to study diseases of the eye,” said Shalev. “But our initial findings indicate that it may be a useful investigative tool for psychological scientists who want to study the link between intelligence and health across the lifespan.”

Source:

http://www.sciencedaily.com/releases/2013/06/130603135533.htm

Eyecare professionals will need to revisit their understanding of the human eye, as scientists at the University of Nottingham recently discovered a new layer in the cornea.

 

Dua’s Layer, named after the academic who discovered it, Professor Harminder Dua, is located at the back of the cornea, between the corneal stroma and Descemet’s membrane. Although it is just 15 microns thick, it is incredibly tough and is strong enough to be able to withstand one and a half to two bars of pressure. This discovery could help patients undergoing corneal grafts and transplants.

 

“This is a major discovery that will mean that ophthalmology textbooks will literally need to be rewritten,” said professor Dua. “Having identified this new and distinct layer deep in the tissue of the cornea, we can now exploit its presence to make operations much safer and simpler for patients. From a clinical perspective, there are many diseases that affect the back of the cornea which clinicians across the world are already beginning to relate to the presence, absence or tear in this layer.”

Sources: http://www.nottingham.ac.uk/news/pressreleases/2013/june/scientists-discover-new-layer-of-the-human-cornea-.aspx

http://www.aaojournal.org/article/S0161-6420(13)00020-1/abstract

Safilo has signed a nine-year licensing agreement with Fendi for the design, manufacture and worldwide distribution of Fendi optical frames and sunglasses and has renewed its licencing agreement with Marc Jacobs until 2024.

 

Marchon has been the worldwide distributor of Fendi eyewear since 2005. The current agreement will be respected until it ends in January 2014.

 

Proud of the agreement, Roberto Vedovotto, CEO of Safilo, says that Fendi’s fashion know-how will be transferred to the new eyewear collections, thanks to Safilo’s expertise. Pietro Beccari, chairman and CEO of Fendi, says that the two groups share common values and intentions and praises Safilo’s obsession for quality and innovation. 

 

Safilo and Marc Jacobs did not wait for the natural end of the current agreement to announce its renewal to December 31, 2024. “The Marc Jacobs and Marc by Marc Jacobs eyewear collections are a huge success and are considered as trendsetters all over the world,” says Roberto Vedovotto, who attributes the success to Marc Jacobs’s irreverent attitude, which is reflected in its designs.

 

Fendi and Marc Jacobs are both part of the LVMH Group.

Sources: http://www.safilo.com/en/PR_2013-06-12_safilo-group-and-fendi-announce-a-new-9-year-licensing-agreement

http://www.safilo.com/en/PR_2013-06-12_safilo-group-and-marc-jacobs-announce-the-early-renewal-of-the-licensing-agreement-for-marc-jacobs-and-marc-by-marc-j_