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Johns Hopkins Researchers Grow Retinal Nerve Cells

In what is hoped to be an important step on the path towards cell transplants for patients with glaucoma or multiple sclerosis, researchers at Johns Hopkins University have developed a method of developing retinal ganglion cells from human stem cells.

Researchers edited the stem cells’ genome to produce a fluorescent protein if another protein, BRN3B, was present. BRN3B is expressed only in mature retinal ganglion cells, so when the stem cells developed into retinal cells they would appear red under a microscope.

The naturally occurring chemical forskolin was added to aid in the transformation from stem cells to retinal ganglion cells. Forskolin is known to modify retinal development in mice, and is sometimes taken as a herbal supplement, though it is not proven as a treatment for any vision disorders.

“Our work could lead not only to a better understanding of the biology of the optic nerve, but also to a cell-based human model that could be used to discover drugs that stop or treat blinding conditions,” says study leader Donald Zack, M.D., Ph.D., the Guerrieri Family Professor of Ophthalmology at the Johns Hopkins University School of Medicine. “And, eventually it could lead to the development of cell transplant therapies that restore vision in patients with glaucoma and MS.”

Further information: http://www.hopkinsmedicine.org/news/media/releases/researchers_grow_retinal_nerve_cells_in_the_lab

Orgreen Finds its Inspiration Everywhere

ORGREEN OPTICS is known for its innovative approach to design, choice of materials, stylistic signature and combination of original colours. Its inspiration comes from all over: cult movies, charismatic individuals, an explosive cocktail, urban culture or the underground artistic scene, and always music…

Four new optical models are now available in the fall-winter collection. And to protect our eyes on bright sunny days, nine new sunglasses are dedicated to albums that never cease to amaze.

Distributed by Prisme Optical Group http://prismeoptical.com

 

Transitions Research: Are You Underserving Multicultural Patients?

PINELLAS PARK, Fla. –  While the vast majority of Canadian eye care professionals (93%) say they serve culturally diverse patients, 40% admit that they do not take steps to educate themselves about culturally diverse patients – and even fewer take proactive steps to connect with these patients, according to a recent survey from Transitions Optical, Inc.[i]Print

“Our consumer research shows that cultural sensitivity is highly valued among Canadians – and with Canadian Millennials such a diverse generation, we expect that this is a trend that will continue,” said Isabelle Tremblay-Dawson, senior marketing manager, Canada, Transitions Optical. “This suggests that eye care professionals could strengthen their relationships with not just multicultural patients, but all patients, by placing more focus on a multicultural strategy.”

For example, according to Tremblay-Dawson, more than three-fourths of Canadians surveyed agree that it is a sign of respect for another’s culture when their eye care professional offers educational materials that are bilingual or in a language other than English or French.[ii] Yet, only 7% of Canadian ECPs surveyed report that they are supplying culturally diverse patients with bilingual/in-language resources.

The survey further revealed that only 34% of ECPs employ bilingual staff members, and even fewer employ diverse staff members (26%). Only 22% offer staff training, 15%  use diverse imagery when marketing and 9% participate in community events.

Transitions Optical offers a number of education resources to help ECPs prepare their practices to meet diverse patient needs through its Transitions Cultural Connections initiative. Several materials, including professional education and bilingual and in-language resources, are available free-of-charge at TransitionsCanadaPRO.ca.

Print

 

[i] Eyecare professional online survey was conducted by Breton Communications on behalf of Transitions Optical, Inc. among 218 professionals (22% optometrists; 63% opticians/dispensers; 15% other) between February 26 and March 13, 2015.

 

[ii] Online survey conducted by Wakefield Research on behalf of Transitions Optical, Inc., among 1,000 Canadian adults, ages 18-69. The survey included oversamples to statistically significant subgroups of Asian Canadians, African Canadians and Aboriginal Canadians and was fielded between February 20th and March 6th, 2015.

 

Anti-epileptic Drug Study to Reveal Scope of Potential Serious Vision Side Effects

The anti-epileptic drug vigabatrin, sold under the brand name Sabril, has as a side effect of mild to severe vision problems and possible permanent loss of vision. This visual field constriction occurs without clinically observable fundal pathology and does not reverse when the patient stops taking vigabatrin. Patients are advised to tell their doctor if they have vision problems such as retinitis or glaucoma before taking vigabatrin, and to have a thorough eye exam before beginning treatment, with eye exams every three months while on the medication to track potential vision loss (www.drugs.com/sabril.html).

The largest prospective study evaluating vision changes in adult patients with refractory complex partial seizures (rCPS) will be available to view next month at the annual meeting of the American Epilepsy Society (AES) in Philadelphia. The single-arm, open-label study enrolled vigabatrin-naïve adult patients to evaluate changes in visual field and retinal structure during one-year exposure to vigabatrin, in addition to other anti-epileptic drugs (AEDs).

“It is crucial that we continue to study the risk of vision loss,” said study investigator Kenneth D. Laxer, MD, professor emeritus of clinical neurology and neurosurgery, University of California San Francisco, and the medical director for the California Pacific Epilepsy Program. “We are looking forward to sharing the largest prospective study evaluating the effect of vigabatrin on vision in adult patients with rCPS.”

Further information: http://www.businesswire.com/news/home/20151125005377/en/Largest-Prospective-Study-Evaluating-Effect-Vigabatrin-Vision

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